Vigabatrin Visual Toxicity: Evolution and Dose Dependence
نویسندگان
چکیده
منابع مشابه
Visual field defects associated with vigabatrin therapy.
OBJECTIVE To estimate the prevalence of visual field defects in patients taking the anticonvulsant drug vigabatrin and to characterise the features of visual dysfunction found. METHODS Thirty three unselected patients attending neurology and epilepsy clinics were identified as taking vigabatrin and asked to attend for neuro-ophthalmic evaluation. A control group of 16 patients with epilepsy u...
متن کاملColeman of vigabatrin induced visual field defects
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متن کاملEvolution of visual field loss over ten years in individuals taking vigabatrin
PURPOSE Vigabatrin-associated visual field loss (VAVFL) occurs in around 45% of exposed people. It is generally accepted that, once established, VAVFL is stable and does not progress with continued VGB use. Most studies have, however, only followed people for short periods. We assessed the evolution of VAVFL over a ten-year period of continued VGB use. METHODS From a group of 201 vigabatrin-e...
متن کاملVigabatrin and Visual Field Defects in Pediatric Epilepsy Patients
We studied the prevalence, type and severity of vigabatrin (VGB)-attributed visual field defects (VFDs), and used these data to assess the associated risk factors in pediatric patients. Medical records were retrospectively reviewed for 67 pediatric patients who received VGB alone or in combination with other antiepileptic drugs, and who had undergone visual field examinations using a Humphrey v...
متن کاملA controlled study of vigabatrin and visual abnormalities.
AIMS To assess the visual function in epileptic patients who have received vigabatrin; to compare this with the visual function in similar epileptic patients who have never received vigabatrin; to investigate whether the severity of visual field defect (VFD) is related to the dose of vigabatrin; to consider other factors that may correlate with the severity of VFD. METHODS 21 consecutive pati...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2001
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.2001.28600.x